Anderlecht are tough opposition on home soil, winning five of their last six European games.
The clubs are meeting for the seventh time with Anderlecht winning two of the previous six matches.
The first of those fixtures – a 10-0 European Cup win for United at Manchester City’s former home, Maine Road, on 26 September 1956 – remains Anderlecht’s heaviest loss, and United’s biggest win, in UEFA competition.
The match will be shown live on BT Sport 2 and streamed live on BTSport.com and via the BT Sport App from 7.30pm. Kick-off 8.05pm.
BT Sport 3 will show Schalke’s visit to Ajax from 8.00pm.